Antituberculosis agent diaportheone B: synthesis, absolute configuration assignment, and anti-TB activity of its analogues

TitleAntituberculosis agent diaportheone B: synthesis, absolute configuration assignment, and anti-TB activity of its analogues
Publication TypeJournal Article
Year of Publication2012
AuthorsSwaroop, PSiva, Raut, GN, Gonnade, RG, Verma, P, Gokhale, RS, D. Reddy, S
JournalOrganic & Biomolecular Chemistry
Volume10
Issue28
Pagination5385-5394
Date PublishedMAY
ISSN1477-0520
Abstract

First synthesis of diaportheone B, an antituberculosis agent isolated from endophytic fungus Diaporthe sp. P133 is reported using two complementary routes, a one step and a three-step sequence. The absolute configuration of diaportheone B was determined by using X-ray crystal structure analysis of its dibromo derivative. In addition, we have prepared several close analogues of diaportheone B and determined their anti-TB potential using Alamar-blue assay (H(37)Rv).

DOI10.1039/c2ob25831e
Type of Journal (Indian or Foreign)

Foreign

Impact Factor (IF)

3.568

Divison category: 
Center for Material Characterization (CMC)
Organic Chemistry