Antimycobacterium activity of coumarins from fruit pulp of aegle marmelos (L.) correa

TitleAntimycobacterium activity of coumarins from fruit pulp of aegle marmelos (L.) correa
Publication TypeJournal Article
Year of Publication2015
AuthorsChinchansure, AA, Shamnani, N, Arkile, MA, Sarkar, D, Joshi, SP
JournalInternational Journal of Basic and Applied Chemical Sciences
Volume5
Issue3
Pagination39-44
Date PublishedJUL
Abstract

Phytochemical investigation of n-butanol fraction of acetone extract of Aegle marmelos fruit has afforded four compounds coumarins marmelosin (1), marmin (2) and xanthotoxol (3) and flavonoid kaempferol 3- O-rhamnoside, afzelin (4). All the isolated compounds were evaluated for their antimycobacterium activity against Mycobacterium tuberculosis H37Ra and Mycobacterium bovis. Compounds 1 and 2 exhibited antimycobacterium activity against M. tuberculosis H37Ra with an IC50 12.46 µg/mL and 4.31 µg/mL respectively whereas, at 100 µg/mL, 62.5% and 82.4% growth inhibition of M. bovis was observed respectively. Compounds 1 and 2 were also evaluated against two gram positive bacteria Staphylococcus aureus, Bacillus subtilis and one gram negative bacteria Escherichia coli. Compound 1 at 100 µg/mL, showed growth inhibition, 64.6% and 74.9% of E. coli and B. subtilis respectively.

Type of Journal (Indian or Foreign)

Foreign

Impact Factor (IF)

1.843

Divison category: 
Biochemical Sciences