Antifungal dimeric chalcone derivative kamalachalcone E from Mallotus philippinensis

TitleAntifungal dimeric chalcone derivative kamalachalcone E from Mallotus philippinensis
Publication TypeJournal Article
Year of Publication2014
AuthorsKulkarni, RR, Tupe, SG, Gample, SP, Chandgude, MG, Sarkar, D, Deshpande, MV, Joshi, SP
JournalNatural Product Research
Date PublishedFEB
Type of ArticleArticle
Keywords4 `-hydroxyrottlerin, antifungal, dimeric chalcone, kamalachalcone E, Mallotus philippinensis, rottlerin

From the red coloured extract (Kamala) prepared through acetone extraction of the fresh whole uncrushed fruits of Mallotus philippinensis, one new dimeric chalcone (1) along with three known compounds 1-(5,7-dihydroxy-2,2,6-trimethyl-2H-1-benzopyran-8-yl)-3-phenyl-2-propen -1-one (2), rottlerin (3) and 4 `-hydroxyrottlerin (4) were isolated. The structure of compound 1 was elucidated by 1D and 2D NMR analyses that included HSQC, HMBC, COSY and ROESY experiments along with the literature comparison. Compounds 1-4 were evaluated for antifungal activity against different human pathogenic yeasts and filamentous fungi. The antiproliferative activity of the compounds was evaluated against Thp-1 cell lines. Compounds 1 and 2 both exhibited IC50 of 8, 4 and 16 mu g/mL against Cryptococcus neoformans PRL518, C. neoformans ATCC32045 and Aspergillus fumigatus, respectively. Compound 4, at 100 mu g/mL, showed 54% growth inhibition of Thp-1 cell lines.

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Organic Chemistry