Analyzing different acetyl co-a metabolizing enzymes as potential drug targets against mycobacterium tuberculosis

TitleAnalyzing different acetyl co-a metabolizing enzymes as potential drug targets against mycobacterium tuberculosis
Publication TypeJournal Article
Year of Publication2015
AuthorsAkhtar, S, Singh, S, Kumar, S, Sarkar, D
JournalBritish Microbiology Research Journal
Volume10
Issue4
Pagination1-15
Date PublishedSEP
Abstract

Mycobacterium tuberculosis, the causative agent of tuberculosis, is responsible for the deaths of million people around the globe. The scenario is worse than ever due to the emergence of drug resistant strains which are widely spread throughout the globe in much faster ways. To control this worst situation, we need to speed up the search for novel drugs which can specifically kill drug resistant bacteria in collaborative ways amongst academic, clinician and industry. Among different metabolic pathways, fatty acid synthesis pathway has always been a very attractive area for the drug target because of its crucial role during the infection and further in long term survival of pathogen inside the human host. In this review article, we analyzed the role of important and crucial enzymes, which are responsible for the influx and efflux of acetyl co-A substrate, a central hub of metabolites, as potential drug targets against M. tuberculosis.

DOI10.9734/BMRJ/2015/19032
Type of Journal (Indian or Foreign)

Foreign

Impact Factor (IF)

31

Divison category: 
Biochemical Sciences