Alpha-Angelica lactone in a new role: facile access to N-Aryl tetrahydroisoquinolinones and isoindolinones via organocatalytic alpha-CH2 oxygenation

TitleAlpha-Angelica lactone in a new role: facile access to N-Aryl tetrahydroisoquinolinones and isoindolinones via organocatalytic alpha-CH2 oxygenation
Publication TypeJournal Article
Year of Publication2019
AuthorsThatikonda, T, Deepake, SK, Das, U
JournalOrganic Letters
Volume21
Issue8
Pagination2532-2535
Date PublishedAPR
Type of ArticleArticle
ISSN1523-7060
Abstract

A method for the direct oxidation of various N-aryl tetrahydroisoquinolines and isoindolines to the corresponding lactams using alpha-angelica lactone as a catalyst was developed. The utility of the method was further demonstrated by synthesis of indoprofen and indobufen.

DOI10.1021/acs.orglett.9b00224
Type of Journal (Indian or Foreign)

Foreign

Impact Factor (IF)

6.555

Divison category: 
Organic Chemistry