(-)-6 alpha-Hydroxy polyanthellin A - a novel antifouling diterpenoid from the Indian soft coral Cladiella krempfi (Hickson)

Title(-)-6 alpha-Hydroxy polyanthellin A - a novel antifouling diterpenoid from the Indian soft coral Cladiella krempfi (Hickson)
Publication TypeJournal Article
Year of Publication2011
AuthorsMol, VPLimna, Raveendran, TV, Parameswaran, PS, Kunnath, RJ, Rajamohanan, PR
JournalCanadian Journal of Chemistry-Revue Canadienne De Chimie
Volume89
Issue1
Pagination57-60
Date PublishedJAN
ISSN0008-4042
Keywordsantifouling, Balanus amphitrite, biofouling, Cladiella krempfi, diterpenes
Abstract

Bioassay-guided purification of methanol extract of the soft coral Cladiella krempfi (Octocorallia: Alcynocea) yielded a novel eunicellin-type diterpenoid, (-)-6 alpha-hydroxy polyanthellin A (1), active against the cyprids of the fouling barnacle, Balanus amphitrite (EC(50) 9.02 mu g/mL; LC(50) 36 mu g/mL; and therapeutic ratio = 4). The structure of compound 1 was determined from its spectral data, including IR, NMR (1D and 2D NMR), and mass spectra.

DOI10.1139/V10-159
Type of Journal (Indian or Foreign)

Foreign

Impact Factor (IF)

0.89

Divison category: 
Central NMR Facility