4 `-Epi-DNA: A DNA Mimic Containing 4 `-hydroxymethyl-alpha-l-Xylo-thymidine with compact backbone like RNA

Title4 `-Epi-DNA: A DNA Mimic Containing 4 `-hydroxymethyl-alpha-l-Xylo-thymidine with compact backbone like RNA
Publication TypeJournal Article
Year of Publication2016
AuthorsBagmare, S, Puranik, VG, Fernandes, M, Kumar, VA
JournalNucleosides Nucleotides & Nucleic Acids
Volume35
Issue9
Pagination445-458
Date PublishedAPR
Type of ArticleArticle
ISSN1525-7770
Keywords4 `-hydroxymethyl nucleosides C4 `-epi-DNA, Antisense Oligonucleotide
Abstract

Synthesis of C4-epi-DNA containing 3 5 linkages is reported for the first time. Crystal structure study of the monomer indicated that though the dihedral angle O3-C3-C4-C5 in this case would be like in RNA, the sugar conformation would remain like that in DNA. The study of the effect of this backbone configuration in DNA with respect to its binding to cDNA and RNA is reported in this note.

DOI10.1080/15257770.2016.1202963
Type of Journal (Indian or Foreign)

Foreign

Impact Factor (IF)

0.831

Divison category: 
Organic Chemistry