1,6-Conjugate-addition-induced [2+1] annulation of para-quinone methides and pyrazolones: synthesis of bis-spiro compounds with contiguous quaternary spiro-centers

Title1,6-Conjugate-addition-induced [2+1] annulation of para-quinone methides and pyrazolones: synthesis of bis-spiro compounds with contiguous quaternary spiro-centers
Publication TypeJournal Article
Year of Publication2019
AuthorsKale, SB, Jori, PK, Thatikonda, T, Gonnade, RG, Das, U
JournalOrganic Letters
Volume21
Issue19
Pagination7736-7740
Date PublishedOCT
Type of ArticleArticle
ISSN1523-7060
Abstract

A diastereoselective formal 1,6-conjugate-addition-mediated [2 + 1] annulation reaction using p-quinone methides and pyrazolones has been described. The corresponding bis-spiro[cyclohexadienone-cyclopropane-pyrazolone] compounds were obtained in very good yield under mild reaction conditions.

DOI10.1021/acs.orglett.9b02641
Type of Journal (Indian or Foreign)

Foreign

Impact Factor (IF)

6.555

Divison category: 
Center for Material Characterization (CMC)
Organic Chemistry